Caffeine as a tool for investigating the integration of Cdc25 phosphorylation, activity and ubiquitin-dependent degradation in Schizosaccharomyces pombe
Abstract The evolutionarily conserved Cdc25 phosphatase is an essential protein that removes inhibitory phosphorylation moieties on the mitotic regulator Cdc2.Together with the Wee1 kinase, a negative regulator of Cdc2 activity, Cdc25 is thus a dale duby obsidian knives central regulator of cell cycle progression in Schizosaccharomyces pombe.The ex